is a software for genome-wide interaction analysis (GWIA) of
case-control SNP data and quantitative traits. SNPs are selected for
joint analysis using a priori information. Sources of information to
define meaningful strategies can be statistical evidence
(single marker association at a moderate level, computed from the own
data) and genetic/biologic relevance (genomic
location, function class or pathway information).
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INTERSNP started as a project of the Institute f. Medical Biometry,
Informatics and Epidemiology, University of Bonn, Germany, and is now
maintained and extended by the AG Genomic Mathematics in
Neuroepidemiology at the German Center for Neurodegenerative Diseases,
Steffens M, Brockschmidt FF, Baur MP, Becker T (2009) INTERSNP:
Genome-wide Interaction Analysis Guided by a priori
Information. Bioinformatics. 2009 Dec 15;25(24):3275-81